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Bone Marrow Soluble Mediator Signatures of Patients with MPNs

Abstract: Background:  Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are clonal hematological diseases classified as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN).  MPN pathogenesis is associated with the presence of somatic driver mutations, bone marrow (BM) niche alterations, and tumor inflammatory status.  The relevance of soluble mediators in the pathogenesis of MPN led us […]

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An elderly couple walks in the park with a male assistant or adult grandson. Caring for the elderly, volunteering

Walking Pace Predicts Clinical Outcomes in Older Adults with Blood Cancers

Slower walking pace linked to a higher likelihood of death and hospital visits; Researchers say gait speed should be used along with other vital signs to better tailor care (WASHINGTON, June 5, 2019) — How slow—or fast—older individuals with blood cancers are able to walk four meters (about 13 feet) holds critical information about their […]

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The-story-of-JAK

Understanding the JAK2 Mutation

THE STORY OF JAK2 Four teams race to find the mysterious cause of a group of blood cancers. JAK2 MUTATIONS AT A GLANCE Involved in: blood cancers and disorders including polycythemia vera, primary myelofibrosis, thrombocythemia, leukemia. Testing requires: a blood draw. Bone marrow samples occasionally used. Prognosis: Patients with a JAK2 mutation have a lower […]

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Incidence, Survival and Prevalence Statistics of Classical Myeloproliferative Neoplasm in Korea

J Korean Med Sci. 2016 Oct;31(10):1579-1585. English. Published online Jul 22, 2016.  http://dx.doi.org/10.3346/jkms.2016.31.10.1579 © 2016 The Korean Academy of Medical Sciences. Incidence, Survival and Prevalence Statistics of Classical Myeloproliferative Neoplasm in Korea Yoojoo Lim, Jeong-Ok Lee and Soo-Mee Bang Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. Address for Correspondence: Soo-Mee Bang, MD. […]

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