Understanding the JAK2 Mutation

THE STORY OF JAK2

Four teams race to find the mysterious cause of a group of blood cancers.

JAK2 MUTATIONS AT A GLANCE

1. Involved in: blood cancers and disorders including polycythemia vera, primary myelofibrosis, thrombocythemia, leukemia.
2. Testing requires: a blood draw. Bone marrow samples occasionally used.
3. Prognosis: Patients with a JAK2 mutation have a lower survival rate and higher rate of blood clots when compared to patients with a CALR mutation.
4. Treatment: Ruxolitinib may improve quality of life in patients with a JAK2 mutation.

This Gene is also known as: JTK10, THCYT3