Contemporary Approach CALR Positive MPNs

Abstract CALR mutations are a revolutionary discovery and represent an important hallmark of myeloproliferative neoplasms (MPN), especially essential thrombocythemia and primary myelofibrosis.  To date, several CALR mutations were identified, with only frameshift mutations linked to the diseased phenotype.  It is of diagnostic and prognostic importance to properly define the type of CALR mutation and subclassify it according to […]

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