May 18, 2021
thumbnail of Bone Marrow Soluble Mediator Signatures of Patients with MPNs

Bone Marrow Soluble Mediator Signatures of Patients with MPNs

Abstract: Background:  Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are clonal hematological diseases classified as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN).  MPN pathogenesis is […]
June 5, 2017
Immunofluorescence of single human cell stained grown in tissue culture, stained with multiple antibodies and visualized via confocal microscopy

A New Therapeutic Target for Myelofibrosis is cause for Gli

Abstract Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor. Bone […]
MPN Cancer Connection
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